When you look at the possibility of being a long-term winner, calculations are based on the standard house edge of the specific wager under consideration. You determine variance, then standard deviation. Now you have the mathematical possibilities for your method of play. Because of variance, there is absolutely the possibility of being a short-term winner, even a semi-long-term winner. Over the lonnnnnnnnnnnng haul (millions of bets), even a simple -1.41% odds against will calculate to be essentially impossible to be a winner. However, if you placed and hit a winner with a bigger bet here and there, anything is possible. If you look at the players BEST POSSIBLE odds against, it would be playing ONE Don't, with 100x odds laid. Nearly the same but slightly better than ONE Do with 100x odds on every bet placed. Assuming you can afford this sort of play, play it and only it every time you play with every bet you make, there is a chance, but still not a good one, that you will be a long-term winner. Obviously, with -0.02% odds against, variance and standard deviations allow for much better mathematical possibilities. For those placing 3 or 4 numbers, pitching some plastic to the stick - hardways, C & E, etc, etc, very best of luck, you'll need it.